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Ellyn · Guest

Sure, I can clarify. I usually try not to bore the ***** out of people unless they want me to. There are multiple reasons for the phenomenal addictive properties of heroin over other opioids.1. Bioavailability (the ratio of medication ingested that is available to the system, usually expressed on percentage) - Since heroin is usually used IV, the bioavailability is nearly 100%. IV meds tend to have a quick onset of action and a higher bioavailability because they bypass first-pass metabolism. You could also inject oxycodone, the opioid on Oxycontin.2. Metabolism - Heroin is metabolized to other active compounds, like the very addictive morphine and 6-MAM. Oxycodone also metabolizes to active compounds.3. Ability to cross the blood-brain barrier - This one is important because if it is not on your brain it will obviously not make you high (or be analgesic). When used IV, heroin is highly lipophilic, even more than morphine, and it crosses into your brain very easily. Oxycodone is also liphophilic but its molecular structure makes it less so than heroin.4. Histamine - When used IV, heroin releases histamine, enhancing the "high"5. Opioid receptor subtypes - This is also important as not all opioids are created equal. We have multiple subtypes of opioid receptors, one subtype receptor family is responsible for analgesia when stimulated, another one causes euphoria and so on... Well, individual medications may have more or less affinity for these particular subtypes. Therefore you some opioid drugs could provide better analgesia than others, and/or as in this case, euphoria (intense high/rush). Of course all of this argument will be purely theoretical if it wasn't for in vivo data, or studies in real people. It is well documented that when given a choice to former addicts (and other mammals), there is a very strong preference for heroin vs other opioids such as fentanyl, oxycodone, meperidine (Demerol) or other similar drugs. Don't get me wrong, the synthetic opioids, like Oxycontin, are highly addictive but heroin is some serious, serious *****. I have been told by addicts that if you ever try heroin, you'll like it so much that they guarantee you will get hooked.If anyone is interested in learning more send me a "shout" here on Digg and we can talk more.
apparently "DavidNiven" hasn't.

Fecanji · Guest

“Yes, quite! None of the Shakespearean plot twists of the original epic, yes? /rolls eyes

Srishti · Guest

Not self righteous at all, each to there own. It was mere observation.I personally can't see the point of putting yourself through that misery. And FTR: I am actually pretty chilled..
Since Digg management hasn't addressed or even apparently noticed the autoplay problem, I think we can reach one of two conclusions:1) This is sanctioned by Digg.2) They all run adblock, even when browsing their own site.Shame on them either way.!

Peregin · Guest

Either the game is really easy and/or has some sort of "aim/jump assist", or the people playing in the first video are ***** amazing at SMB.?
"He must have really sprung for the realistic stuff this year!"

Rylin · Guest

Chek out the big brain on yocouchdigga!

Schavemaker · Guest

This is why I play rugby.

Zakry · Guest

My sex life in a nutshell

Kristine · Guest

!

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